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Physical tethering and volume exclusion determine higher-order genome organization in budding yeast

In this paper we show that tethering of heterochromatic regions to nuclear landmarks and random encounters of chromosomes in the confined nuclear volume are sufficient to explain the higher-order organization of the budding yeast genome. We have quantitatively characterized the contact patterns and...

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Detalles Bibliográficos
Autores principales: Tjong, Harianto, Gong, Ke, Chen, Lin, Alber, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396370/
https://www.ncbi.nlm.nih.gov/pubmed/22619363
http://dx.doi.org/10.1101/gr.129437.111