Targeted gene addition to a predetermined site in the human genome using a ZFN-based nicking enzyme

Zinc-finger nucleases (ZFNs) drive highly efficient genome editing by generating a site-specific DNA double-strand break (DSB) at a predetermined site in the genome. Subsequent repair of this break via the nonhomologous end-joining (NHEJ) or homology-directed repair (HDR) pathways results in targete...

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Detalles Bibliográficos
Autores principales: Wang, Jianbin, Friedman, Geoffrey, Doyon, Yannick, Wang, Nathaniel S., Li, Carrie Jiaxin, Miller, Jeffrey C., Hua, Kevin L., Yan, Jenny Jiacheng, Babiarz, Joshua E., Gregory, Philip D., Holmes, Michael C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2012
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396372/
https://www.ncbi.nlm.nih.gov/pubmed/22434427
http://dx.doi.org/10.1101/gr.122879.111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396372/
https://www.ncbi.nlm.nih.gov/pubmed/22434427
http://dx.doi.org/10.1101/gr.122879.111

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