Precision genome engineering with programmable DNA-nicking enzymes

Zinc finger nucleases (ZFNs) are powerful tools of genome engineering but are limited by their inevitable reliance on error-prone nonhomologous end-joining (NHEJ) repair of DNA double-strand breaks (DSBs), which gives rise to randomly generated, unwanted small insertions or deletions (indels) at bot...

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Detalles Bibliográficos
Autores principales: Kim, Eunji, Kim, Sojung, Kim, Duk Hyoung, Choi, Beom-Soon, Choi, Ik-Young, Kim, Jin-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2012
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396373/
https://www.ncbi.nlm.nih.gov/pubmed/22522391
http://dx.doi.org/10.1101/gr.138792.112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396373/
https://www.ncbi.nlm.nih.gov/pubmed/22522391
http://dx.doi.org/10.1101/gr.138792.112

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