A CD4 T cell gene signature for early rheumatoid arthritis implicates interleukin 6-mediated STAT3 signalling, particularly in anti-citrullinated peptide antibody-negative disease

OBJECTIVE: We sought clinically relevant predictive biomarkers present in CD4 T-cells, or in serum, that identified those patients with undifferentiated arthritis (UA) who subsequently develop rheumatoid arthritis (RA). METHODS: Total RNA was isolated from highly purified peripheral blood CD4 T cell...

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Detalles Bibliográficos
Autores principales: Pratt, Arthur G, Swan, Daniel C, Richardson, Sarah, Wilson, Gillian, Hilkens, Catharien M U, Young, David A, Isaacs, John D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Group 2012
Materias:
Basic and Translational Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396452/
https://www.ncbi.nlm.nih.gov/pubmed/22532634
http://dx.doi.org/10.1136/annrheumdis-2011-200968

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396452/
https://www.ncbi.nlm.nih.gov/pubmed/22532634
http://dx.doi.org/10.1136/annrheumdis-2011-200968

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