Cargando…

A Novel Chimpanzee Adenovirus Vector with Low Human Seroprevalence: Improved Systems for Vector Derivation and Comparative Immunogenicity

Recombinant adenoviruses are among the most promising tools for vaccine antigen delivery. Recently, the development of new vectors has focused on serotypes to which the human population is less exposed in order to circumvent pre-existing anti vector immunity. This study describes the derivation of a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dicks, Matthew D. J., Spencer, Alexandra J., Edwards, Nick J., Wadell, Göran, Bojang, Kalifa, Gilbert, Sarah C., Hill, Adrian V. S., Cottingham, Matthew G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396660/ https://www.ncbi.nlm.nih.gov/pubmed/22808149 http://dx.doi.org/10.1371/journal.pone.0040385

Ejemplares similares

Immunogenicity and efficacy of a chimpanzee adenovirus-vectored Rift Valley Fever vaccine in mice
por: Warimwe, George M, et al.
Publicado: (2013)

Differential immunogenicity between HAdV-5 and chimpanzee adenovirus vector ChAdOx1 is independent of fiber and penton RGD loop sequences in mice
por: Dicks, Matthew D. J., et al.
Publicado: (2015)

The relative magnitude of transgene-specific adaptive immune responses induced by human and chimpanzee adenovirus vectors differs between laboratory animals and a target species
por: Dicks, Matthew D.J., et al.
Publicado: (2015)

Chimpanzee adenoviral vectors as vaccines for outbreak pathogens
por: Ewer, Katie, et al.
Publicado: (2017)

Simian adenoviruses as vaccine vectors
por: Morris, Susan J, et al.
Publicado: (2016)

Transgene Optimization, Immunogenicity and In Vitro Efficacy of Viral Vectored Vaccines Expressing Two Alleles of Plasmodium falciparum AMA1
por: Biswas, Sumi, et al.
Publicado: (2011)

Mixed Vector Immunization With Recombinant Adenovirus and MVA Can Improve Vaccine Efficacy While Decreasing Antivector Immunity
por: Reyes-Sandoval, Arturo, et al.
Publicado: (2012)

Safety and Immunogenicity of a Novel Recombinant Simian Adenovirus ChAdOx2 as a Vectored Vaccine
por: Folegatti, Pedro M., et al.
Publicado: (2019)

4-1BBL Enhances CD8(+) T Cell Responses Induced by Vectored Vaccines in Mice but Fails to Improve Immunogenicity in Rhesus Macaques
por: Spencer, Alexandra J., et al.
Publicado: (2014)

Innate Immune Responses to Chimpanzee Adenovirus Vector 155 Vaccination in Mice and Monkeys
por: Collignon, Catherine, et al.
Publicado: (2020)

STING-pathway modulation to enhance the immunogenicity of adenoviral-vectored vaccines
por: Padron-Regalado, Eriko, et al.
Publicado: (2022)

Preclinical immunogenicity of an adenovirus-vectored vaccine for herpes zoster
por: Ulaszewska, Marta, et al.
Publicado: (2023)

Manufacturing a chimpanzee adenovirus‐vectored SARS‐CoV‐2 vaccine to meet global needs
por: Joe, Carina C. D., et al.
Publicado: (2021)

Low Seroprevalent Species D Adenovirus Vectors as Influenza Vaccines
por: Weaver, Eric A., et al.
Publicado: (2013)

Safety and Immunogenicity of Adenovirus and Poxvirus Vectored Vaccines against a Mycobacterium Avium Complex Subspecies
por: Folegatti, Pedro M., et al.
Publicado: (2021)

Modification of Adenovirus vaccine vector-induced immune responses by expression of a signalling molecule
por: Rollier, Christine S., et al.
Publicado: (2020)

Analysis of T cell responses to chimpanzee adenovirus vectors encoding HIV gag–pol–nef antigen
por: Herath, S., et al.
Publicado: (2015)

Adenovirus vector and mRNA vaccines: Mechanisms regulating their immunogenicity
por: Provine, Nicholas M., et al.
Publicado: (2022)

Clinical Assessment of a Novel Recombinant Simian Adenovirus ChAdOx1 as a Vectored Vaccine Expressing Conserved Influenza A Antigens
por: Antrobus, Richard D, et al.
Publicado: (2014)

Transcriptomic response and immunological responses to chimpanzee adenovirus- and MVA viral-vectored vaccines for RSV in healthy adults
por: Green, C, et al.
Publicado: (2023)

Adenoviruses as vaccine vectors
por: Tatsis, Nia, et al.
Publicado: (2004)

Utilizing poxviral vectored vaccines for antibody induction—Progress and prospects
por: Draper, Simon J., et al.
Publicado: (2013)

Optimising Immunogenicity with Viral Vectors: Mixing MVA and HAdV-5 Expressing the Mycobacterial Antigen Ag85A in a Single Injection
por: Betts, Gareth, et al.
Publicado: (2012)

Immune Thrombocytopenia Induced by the Chimpanzee Adenovirus-Vectored Vaccine against SARS-CoV-2 Infection
por: Liao, Po-Wei, et al.
Publicado: (2021)

Correlates of Protection Against SIV(mac251) Infection in Rhesus Macaques Immunized With Chimpanzee-Derived Adenovirus Vectors
por: Tuyishime, Steven, et al.
Publicado: (2018)

Seroprevalence of Neutralizing Antibodies against Human Adenovirus Type-5 and Chimpanzee Adenovirus Type-68 in Cancer Patients
por: Zhao, Hua, et al.
Publicado: (2018)

Strain-dependent and distinctive T-cell responses to HIV antigens following immunisation of mice with differing chimpanzee adenovirus vaccine vectors
por: Herath, S., et al.
Publicado: (2016)

Cytokine Responses to Adenovirus and Adenovirus Vectors
por: Atasheva, Svetlana, et al.
Publicado: (2022)

Covalent decoration of adenovirus vector capsids with the carbohydrate epitope αGal does not improve vector immunogenicity, but allows to study the in vivo fate of adenovirus immunocomplexes
por: Kratzer, Ramona F., et al.
Publicado: (2017)

Comparative assessment of vaccine vectors encoding ten malaria antigens identifies two protective liver-stage candidates
por: Longley, Rhea J., et al.
Publicado: (2015)

Both chimpanzee adenovirus-vectored and DNA vaccines induced long-term immunity against Nipah virus infection
por: Lu, Mingqing, et al.
Publicado: (2023)

Safety and High Level Efficacy of the Combination Malaria Vaccine Regimen of RTS,S/AS01(B) With Chimpanzee Adenovirus 63 and Modified Vaccinia Ankara Vectored Vaccines Expressing ME-TRAP
por: Rampling, Tommy, et al.
Publicado: (2016)

Tailoring subunit vaccine immunogenicity: Maximizing antibody and T cell responses by using combinations of adenovirus, poxvirus and protein-adjuvant vaccines against Plasmodium falciparum MSP1()
por: Douglas, Alexander D., et al.
Publicado: (2010)

Stability of Chimpanzee Adenovirus Vectored Vaccines (ChAdOx1 and ChAdOx2) in Liquid and Lyophilised Formulations
por: Berg, Adam, et al.
Publicado: (2021)

Phase Ia Clinical Evaluation of the Safety and Immunogenicity of the Plasmodium falciparum Blood-Stage Antigen AMA1 in ChAd63 and MVA Vaccine Vectors
por: Sheehy, Susanne H., et al.
Publicado: (2012)

A single intranasal or intramuscular immunization with chimpanzee adenovirus-vectored SARS-CoV-2 vaccine protects against pneumonia in hamsters
por: Bricker, Traci L., et al.
Publicado: (2021)

Comparison of Immunogenicity and Safety of Inactivated, Adenovirus-Vectored, and Heterologous Adenovirus-Vectored/mRNA Vaccines in Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis: A Prospective Cohort Study
por: Assawasaksakul, Theerada, et al.
Publicado: (2022)

Guillain-Barre syndrome following the first dose of the chimpanzee adenovirus-vectored COVID-19 vaccine, ChAdOx1
por: Patel, Shreena Umit, et al.
Publicado: (2021)

Heterologous chimpanzee adenovirus vector immunizations for SARS-CoV-2 spike and nucleocapsid protect hamsters against COVID-19
por: Hasanpourghadi, Mohadeseh, et al.
Publicado: (2023)

Impact of Preexisting Adenovirus Vector Immunity on Immunogenicity and Protection Conferred with an Adenovirus-Based H5N1 Influenza Vaccine
por: Pandey, Aseem, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_8tvcmldrn5316o0pgbsihk3gvr