Cargando…
IL-6 triggers IL-21 production by human CD4(+) T cells to drive STAT3-dependent plasma cell differentiation in B cells
Interleukin (IL)-21-producing CD4(+) T cells are central to humoral immunity. Deciphering the signals that induce IL-21 production in CD4(+) T cells and those triggered by IL-21 in B cells are, therefore, of importance for understanding the generation of antibody responses. Here, we show that IL-6 i...
Autores principales: | Diehl, Sean A., Schmidlin, Heike, Nagasawa, Maho, Blom, Bianca, Spits, Hergen |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396759/ https://www.ncbi.nlm.nih.gov/pubmed/22491065 http://dx.doi.org/10.1038/icb.2012.17 |
Ejemplares similares
-
Human CD5(+) Innate Lymphoid Cells Are Functionally Immature and Their Development from CD34(+) Progenitor Cells Is Regulated by Id2
por: Nagasawa, Maho, et al.
Publicado: (2017) -
The ETS Transcription Factor Spi-B Is Required for Human Plasmacytoid Dendritic Cell Development
por: Schotte, Remko, et al.
Publicado: (2004) -
IL-1β, IL-23, and TGF-β drive plasticity of human ILC2s towards IL-17-producing ILCs in nasal inflammation
por: Golebski, Korneliusz, et al.
Publicado: (2019) -
T cell–independent development and induction of somatic hypermutation in human IgM(+)IgD(+)CD27(+) B cells
por: Scheeren, Ferenc A., et al.
Publicado: (2008) -
Downregulation of CD1 Marks Acquisition of Functional Maturation of Human Thymocytes and Defines a Control Point in Late Stages of Human T Cell Development
por: Res, Pieter, et al.
Publicado: (1997)