Mechanism of Generation of Therapy Related Leukemia in Response to Anti-Topoisomerase II Agents

Type II DNA topoisomerases have the ability to generate a transient DNA double-strand break through which a second duplex can be passed; an activity essential for DNA decatenation and unknotting. Topoisomerase poisons stabilize the normally transient topoisomerase-induced DSBs and are potent and wid...

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Detalles Bibliográficos
Autores principales: Cowell, Ian G., Austin, Caroline A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397365/
https://www.ncbi.nlm.nih.gov/pubmed/22829791
http://dx.doi.org/10.3390/ijerph9062075

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397365/
https://www.ncbi.nlm.nih.gov/pubmed/22829791
http://dx.doi.org/10.3390/ijerph9062075

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