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Mechanism of Generation of Therapy Related Leukemia in Response to Anti-Topoisomerase II Agents
Type II DNA topoisomerases have the ability to generate a transient DNA double-strand break through which a second duplex can be passed; an activity essential for DNA decatenation and unknotting. Topoisomerase poisons stabilize the normally transient topoisomerase-induced DSBs and are potent and wid...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397365/ https://www.ncbi.nlm.nih.gov/pubmed/22829791 http://dx.doi.org/10.3390/ijerph9062075 |