Cargando…

“Scanning mutagenesis” of the amino acid sequences flanking phosphorylation site 1 of the mitochondrial pyruvate dehydrogenase complex

The mitochondrial pyruvate dehydrogenase complex (mtPDC) is regulated by reversible seryl-phosphorylation of the E1α subunit by a dedicated, intrinsic kinase. The phospho-complex is reactivated when dephosphorylated by an intrinsic PP2C-type protein phosphatase. Both the position of the phosphorylat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ahsan, Nagib, Swatek, Kirby N., Zhang, Jingfen, Miernyk, Ján A., Xu, Dong, Thelen, Jay J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2012
Materias:	Plant Science
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397410/ https://www.ncbi.nlm.nih.gov/pubmed/22811682 http://dx.doi.org/10.3389/fpls.2012.00153

Ejemplares similares

Asp295 Stabilizes the Active-Site Loop Structure of Pyruvate Dehydrogenase, Facilitating Phosphorylation of Ser292 by Pyruvate Dehydrogenase-Kinase
por: Hirani, Tripty A., et al.
Publicado: (2011)

Circles within circles: crosstalk between protein Ser/Thr/Tyr-phosphorylation and Met oxidation
por: Rao, R Shyama Prasad, et al.
Publicado: (2013)

The pyruvate dehydrogenase complex regulates mitophagic trafficking and protein phosphorylation
por: Kolitsida, Panagiota, et al.
Publicado: (2023)

Regulation of the Regulators: Post-Translational Modifications, Subcellular, and Spatiotemporal Distribution of Plant 14-3-3 Proteins
por: Wilson, Rashaun S., et al.
Publicado: (2016)

Extracellular ATP elicits DORN1-mediated RBOHD phosphorylation to regulate stomatal aperture
por: Chen, Dongqin, et al.
Publicado: (2017)

Association of Phosphorylated Pyruvate Dehydrogenase with Pyruvate Kinase M2 Promotes PKM2 Stability in Response to Insulin
por: Hossain, Abu Jubayer, et al.
Publicado: (2023)

Hexokinase II promotes the Warburg effect by phosphorylating alpha subunit of pyruvate dehydrogenase
por: Luo, Fangxiu, et al.
Publicado: (2019)

Site Saturation Mutagenesis Applications on Candida methylica Formate Dehydrogenase
por: Özgün, Gülşah P., et al.
Publicado: (2016)

How phosphorylation influences E1 subunit pyruvate dehydrogenase: A computational study
por: Sgrignani, Jacopo, et al.
Publicado: (2018)

Regulation of hepatic pyruvate dehydrogenase phosphorylation in offspring glucose intolerance induced by intrauterine hyperglycemia
por: Zhang, Yong, et al.
Publicado: (2017)

Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism
por: Park, Sungmi, et al.
Publicado: (2018)

Phosphorylation of the pyruvate dehydrogenase complex precedes HIF-1-mediated effects and pyruvate dehydrogenase kinase 1 upregulation during the first hours of hypoxic treatment in hepatocellular carcinoma cells
por: Zimmer, Andreas David, et al.
Publicado: (2016)

Pyruvate Dehydrogenase A1 Phosphorylated by Insulin Associates with Pyruvate Kinase M2 and Induces LINC00273 through Histone Acetylation
por: Hossain, Abu Jubayer, et al.
Publicado: (2022)

Phosphonate Inhibitors of Pyruvate Dehydrogenase Perturb Homeostasis of Amino Acids and Protein Succinylation in the Brain
por: Artiukhov, Artem V., et al.
Publicado: (2022)

Role of pyruvate dehydrogenase complex in traumatic brain injury and Measurement of pyruvate dehydrogenase enzyme by dipstick test
por: Sharma, Pushpa, et al.
Publicado: (2009)

Effects of arsenic on pyruvate dehydrogenase activation.
por: Schiller, C M, et al.
Publicado: (1977)

Transcriptional Regulation of Pyruvate Dehydrogenase Kinase
por: Jeong, Ji Yun, et al.
Publicado: (2012)

Pyruvate dehydrogenase levels are low in sepsis
por: Nuzzo, E, et al.
Publicado: (2015)

In silico analysis of protein Lys-N(𝜀)-acetylation in plants
por: Rao, R. Shyama Prasad, et al.
Publicado: (2014)

Activating oxidative phosphorylation by a pyruvate dehydrogenase kinase inhibitor overcomes sorafenib resistance of hepatocellular carcinoma
por: Shen, Y-C, et al.
Publicado: (2013)

Pyruvate Dehydrogenase Kinase 4 Promotes Vascular Calcification via SMAD1/5/8 Phosphorylation
por: Lee, Sun Joo, et al.
Publicado: (2015)

Src drives the Warburg effect and therapy resistance by inactivating pyruvate dehydrogenase through tyrosine-289 phosphorylation
por: Jin, Yue, et al.
Publicado: (2016)

Pyruvate Dehydrogenase Kinase 1 inhibition mediated oxidative phosphorylation enhancement in cartilage promotes osteoarthritis progression
por: Yang, Xian, et al.
Publicado: (2023)

Predicting and Analyzing Protein Phosphorylation Sites in Plants Using Musite
por: Yao, Qiuming, et al.
Publicado: (2012)

ABS–Scan: In silico alanine scanning mutagenesis for binding site residues in protein–ligand complex
por: Anand, Praveen, et al.
Publicado: (2014)

The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity
por: Lee, In-Kyu
Publicado: (2014)

Phenylbutyrate increases activity of pyruvate dehydrogenase complex
por: Ferriero, Rosa, et al.
Publicado: (2013)

Novel O-palmitolylated beta-E1 subunit of pyruvate dehydrogenase is phosphorylated during ischemia/reperfusion injury
por: Folmes, Clifford DL, et al.
Publicado: (2010)

Corrigendum: Pyruvate Dehydrogenase Kinase 4 Promotes Vascular Calcification via SMAD1/5/8 Phosphorylation
por: Lee, Sun Joo, et al.
Publicado: (2016)

Mitochondria directly sense osmotic stress to trigger rapid metabolic remodeling via regulation of pyruvate dehydrogenase phosphorylation
por: Ikizawa, Takeshi, et al.
Publicado: (2022)

Massively Parallel Single Amino Acid Mutagenesis
por: Kitzman, Jacob O., et al.
Publicado: (2015)

Pyruvate dehydrogenase complex and lactate dehydrogenase are targets for therapy of acute liver failure
por: Ferriero, Rosa, et al.
Publicado: (2018)

Mitochondrial hydrogen peroxide production by pyruvate dehydrogenase and α-ketoglutarate dehydrogenase in oxidative eustress and oxidative distress
por: Chalifoux, Olivia, et al.
Publicado: (2023)

A novel null mutation in the pyruvate dehydrogenase phosphatase catalytic subunit gene (PDP1) causing pyruvate dehydrogenase complex deficiency
por: Bedoyan, Jirair K., et al.
Publicado: (2019)

Phosphorylated form of pyruvate dehydrogenase α1 mediates tumor necrosis factor α-induced glioma cell migration
por: Yang, Zijun, et al.
Publicado: (2021)

Probing the Role of the Conserved Arg174 in Formate Dehydrogenase by Chemical Modification and Site-Directed Mutagenesis
por: Alqarni, Mohammed Hamed, et al.
Publicado: (2021)

Dichloroacetate and Pyruvate Metabolism: Pyruvate Dehydrogenase Kinases as Targets Worth Investigating for Effective Therapy of Toxoplasmosis
por: Ferrarini, Mariana Galvão, et al.
Publicado: (2021)

The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility
por: Zhang, Shuai, et al.
Publicado: (2014)

Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers
por: Jeoung, Nam Ho
Publicado: (2015)

Pyruvate dehydrogenase complex in cerebral ischemia-reperfusion injury
por: Thibodeau, Alexa, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_kqq362bslpeb1sp8c1bi8al11k