Cargando…

A Computational Study on Thiourea Analogs as Potent MK-2 Inhibitors

Mitogen-activated protein kinase-activated protein kinase 2 (MK-2) has been identified as a drug target for the treatment of inflammatory diseases. Currently, a series of thiourea analogs as potent MK-2 inhibitors were studied using comprehensive computational methods by 3D-QSAR, molecular docking a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hao, Ming, Ren, Hong, Luo, Fang, Zhang, Shuwei, Qiu, Jieshan, Ji, Mingjuan, Si, Hongzong, Li, Guohui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Molecular Diversity Preservation International (MDPI) 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397511/ https://www.ncbi.nlm.nih.gov/pubmed/22837679 http://dx.doi.org/10.3390/ijms13067057

Ejemplares similares

In Silico Identification of Structure Requirement for Novel Thiazole and Oxazole Derivatives as Potent Fructose 1,6-Bisphosphatase Inhibitors
por: Hao, Ming, et al.
Publicado: (2011)

Toward the Prediction of FBPase Inhibitory Activity Using Chemoinformatic Methods
por: Hao, Ming, et al.
Publicado: (2012)

Design and Discovery of Quinazoline- and Thiourea-Containing Sorafenib Analogs as EGFR and VEGFR-2 Dual TK Inhibitors
por: Sun, Shaofeng, et al.
Publicado: (2017)

Analysis of 1-Aroyl-3-[3-chloro-2-methylphenyl] Thiourea Hybrids as Potent Urease Inhibitors: Synthesis, Biochemical Evaluation and Computational Approach
por: Rasheed, Samina, et al.
Publicado: (2022)

Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia
por: Layton, Mark E., et al.
Publicado: (2023)

Adenosine Analog NITD008 Is a Potent Inhibitor of Zika Virus
por: Deng, Yong-Qiang, et al.
Publicado: (2016)

Repositioning of Thiourea-Containing Drugs as Tyrosinase Inhibitors
por: Choi, Joonhyeok, et al.
Publicado: (2015)

2-acetylphenol analogs as potent reversible monoamine oxidase inhibitors
por: Legoabe, Lesetja J, et al.
Publicado: (2015)

MK256 is a novel CDK8 inhibitor with potent antitumor activity in AML through downregulation of the STAT pathway
por: Lee, Jen-Chieh, et al.
Publicado: (2022)

Novel Sulfonamide Analogs of Sivelestat as Potent Human Neutrophil Elastase Inhibitors
por: Crocetti, Letizia, et al.
Publicado: (2020)

Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2
por: Gurgis, FMS, et al.
Publicado: (2015)

Accelerated first-in-human clinical trial of EIDD-2801/MK-4482 (molnupiravir), a ribonucleoside analog with potent antiviral activity against SARS-CoV-2
por: Holman, Wendy, et al.
Publicado: (2021)

Synthesis of Sterically Encumbered Thiourea S‐Oxides through Direct Thiourea Oxidation
por: Medvedko, Serhii, et al.
Publicado: (2022)

Discovery of Quercetin and Its Analogs as Potent OXA-48 Beta-Lactamase Inhibitors
por: Zhang, Yuejuan, et al.
Publicado: (2022)

Antidepressant Effects of (+)-MK-801 and (-)-MK-801 in the Social Defeat Stress Model
por: Yang, Bangkun, et al.
Publicado: (2016)

Exploration of Thiourea-Based Scaffolds for the Construction of Bacterial Ureases Inhibitors
por: Tabor, Wojciech, et al.
Publicado: (2023)

Computational Insights into the Inhibitory Mechanism of Human AKT1 by an Orally Active Inhibitor, MK-2206
por: Rehan, Mohd, et al.
Publicado: (2014)

New insights into morphological, stereological and functional studies of the adrenal gland under exposure to the potent goitrogen thiourea
por: Chakraborty, Arijit, et al.
Publicado: (2018)

Synthesis, predictions of drug-likeness, and pharmacokinetic properties of some chiral thioureas as potent enzyme inhibition agents
por: SICAK, Yusuf
Publicado: (2021)

Synthesis of Chromen-4-One-Oxadiazole Substituted Analogs as Potent β-Glucuronidase Inhibitors
por: Taha, Muhammad, et al.
Publicado: (2019)

Thiourea Derivatives, Simple in Structure but Efficient Enzyme Inhibitors and Mercury Sensors
por: Rahman, Faizan Ur, et al.
Publicado: (2021)

Synthesis and Evaluation of Amide and Thiourea Derivatives as Carbonic Anhydrase (CA) Inhibitors
por: Hussain, Zahid, et al.
Publicado: (2022)

8-cyanobenzothiazinone analogs with potent antitubercular activity
por: Zhang, Gang, et al.
Publicado: (2021)

Structural Optimization of BIPPO Analogs as Potent Antimalarials
por: Zheng, Yang, et al.
Publicado: (2023)

Pulmonary toxicity of thioureas in the rat.
por: Scott, A M, et al.
Publicado: (1990)

Cyclopamine analogs bearing exocyclic methylenes are highly potent and acid-stable inhibitors of hedgehog signaling
por: Moschner, Johann, et al.
Publicado: (2013)

Synthesis and Bioactivity of Pyrazole Acyl Thiourea Derivatives
por: Wu, Jian, et al.
Publicado: (2012)

Characterization of Potent Fusion Inhibitors of Influenza Virus
por: Rowse, Michael, et al.
Publicado: (2015)

Pentafluorosulfanyl-containing Triclocarban Analogs with Potent Antimicrobial Activity
por: Pujol, Eugènia, et al.
Publicado: (2018)

Synthesis and evaluation of potent yaku'amide A analogs
por: Lo, Concordia C. L., et al.
Publicado: (2022)

Investigating the effects of two novel 4-MMPB analogs as potent lipoxygenase inhibitors for prostate cancer treatment
por: Iranpour, Sonia, et al.
Publicado: (2021)

Matrix Stiffness Affects Endocytic Uptake of MK2-Inhibitor Peptides
por: Brugnano, Jamie L., et al.
Publicado: (2014)

Deciphering the true antiproliferative target of an MK2 activation inhibitor in glioblastoma
por: Brennan, P E
Publicado: (2016)

The acid–base and redox properties of menaquinone MK-4, MK-7, and MK-9 (vitamin K(2)) in DMPC monolayers on mercury
por: Dharmaraj, Karuppasamy, et al.
Publicado: (2020)

Thiourea and Related Compounds in the Treatment of Hyperthyroidism
por: Winkler, A. W., et al.
Publicado: (1946)

The dual role of thiourea in the thiotrifluoromethylation of alkenes
por: Ricci, Paolo, et al.
Publicado: (2017)

Mechanochemical synthesis of thioureas, ureas and guanidines
por: Štrukil, Vjekoslav
Publicado: (2017)

Synthesis of Chiral Thiourea-Thioxanthone Hybrids
por: Mayr, Florian, et al.
Publicado: (2017)

Natural Potent NAAA Inhibitor Atractylodin Counteracts LPS-Induced Microglial Activation
por: Yang, Longhe, et al.
Publicado: (2020)

Discovery of MK-1421, a Potent, Selective sstr3 Antagonist, as a Development Candidate for Type 2 Diabetes
por: Shah, Shrenik K., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_5uq9vics1a1ncnfih2gkum7bta