Nec-1 Enhances Shikonin-Induced Apoptosis in Leukemia Cells by Inhibition of RIP-1 and ERK1/2

Necrostatin-1 (Nec-1) inhibits necroptosis by allosterically inhibiting the kinase activity of receptor-interacting protein 1 (RIP1), which plays a critical role in necroptosis. RIP1 is a crucial adaptor kinase involved in the activation of NF-κB, production of reactive oxygen species (ROS) and the...

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Detalles Bibliográficos
Autores principales: Han, Weidong, Xie, Jiansheng, Fang, Yong, Wang, Zhanggui, Pan, Hongming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397521/
https://www.ncbi.nlm.nih.gov/pubmed/22837689
http://dx.doi.org/10.3390/ijms13067212

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397521/
https://www.ncbi.nlm.nih.gov/pubmed/22837689
http://dx.doi.org/10.3390/ijms13067212

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