Prediction of a New Ligand-Binding Site for Type 2 Motif based on the Crystal Structure of ALG-2 by Dry and Wet Approaches

ALG-2 is a penta-EF-hand Ca(2+)-binding protein and interacts with a variety of intracellular proteins. Two types of ALG-2-binding motifs have been determined: type 1, PXYPXnYP (X, variable; n = 4), in ALIX and PLSCR3; type 2, PXPGF, in Sec31A and PLSCR3. The previously solved X-ray crystal structur...

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Detalles Bibliográficos
Autores principales: Takahashi, Takeshi, Suzuki, Hironori, Inuzuka, Tatsutoshi, Shibata, Hideki, Maki, Masatoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397542/
https://www.ncbi.nlm.nih.gov/pubmed/22837710
http://dx.doi.org/10.3390/ijms13067532

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397542/
https://www.ncbi.nlm.nih.gov/pubmed/22837710
http://dx.doi.org/10.3390/ijms13067532

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