The Role of PPARα in Metformin-Induced Attenuation of Mitochondrial Dysfunction in Acute Cardiac Ischemia/Reperfusion in Rats

Metformin, an anti-diabetic drug, exerts cardioprotection against ischemia-reperfusion (IR) through the activation of AMPK. However, the molecular mechanisms underlying these beneficial effects remain elusive. In this study, we examined the role of PPARα in mediating cardioprotective effects of metf...

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Detalles Bibliográficos
Autores principales: Barreto-Torres, Giselle, Parodi-Rullán, Rebecca, Javadov, Sabzali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397554/
https://www.ncbi.nlm.nih.gov/pubmed/22837722
http://dx.doi.org/10.3390/ijms13067694

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397554/
https://www.ncbi.nlm.nih.gov/pubmed/22837722
http://dx.doi.org/10.3390/ijms13067694

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