Crystal structure of Onconase at 1.1 Å resolution – insights into substrate binding and collective motion

Onconase® (ONC) is an amphibian member of the pancreatic ribonuclease superfamily that is selectively toxic to tumor cells. It is a much less efficient enzyme than the archetypal ribonuclease A and, in an attempt to gain further insight, we report the first atomic resolution crystal structure of ONC...

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Detalles Bibliográficos
Autores principales: Holloway, Daniel E, Singh, Umesh P, Shogen, Kuslima, Acharya, K Ravi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2011
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397563/
https://www.ncbi.nlm.nih.gov/pubmed/21895975
http://dx.doi.org/10.1111/j.1742-4658.2011.08320.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397563/
https://www.ncbi.nlm.nih.gov/pubmed/21895975
http://dx.doi.org/10.1111/j.1742-4658.2011.08320.x

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