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Crystal structure of Onconase at 1.1 Å resolution – insights into substrate binding and collective motion
Onconase® (ONC) is an amphibian member of the pancreatic ribonuclease superfamily that is selectively toxic to tumor cells. It is a much less efficient enzyme than the archetypal ribonuclease A and, in an attempt to gain further insight, we report the first atomic resolution crystal structure of ONC...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Blackwell Publishing Ltd
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397563/ https://www.ncbi.nlm.nih.gov/pubmed/21895975 http://dx.doi.org/10.1111/j.1742-4658.2011.08320.x |