Constructing Endophenotypes of Complex Diseases Using Non-Negative Matrix Factorization and Adjusted Rand Index

Complex diseases are typically caused by combinations of molecular disturbances that vary widely among different patients. Endophenotypes, a combination of genetic factors associated with a disease, offer a simplified approach to dissect complex trait by reducing genetic heterogeneity. Because molec...

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Detalles Bibliográficos
Autores principales: Wang, Hui-Min, Hsiao, Ching-Lin, Hsieh, Ai-Ru, Lin, Ying-Chao, Fann, Cathy S. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397992/
https://www.ncbi.nlm.nih.gov/pubmed/22815890
http://dx.doi.org/10.1371/journal.pone.0040996

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397992/
https://www.ncbi.nlm.nih.gov/pubmed/22815890
http://dx.doi.org/10.1371/journal.pone.0040996

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