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The deubiquitinylation and localization of PTEN are regulated by a HAUSP–PML network
Nuclear exclusion of the PTEN tumour suppressor has been associated with cancer progression(1-6). However, the mechanisms leading to this aberrant PTEN localization in human cancers are currently unknown. We have previously reported that ubiquitinylation of PTEN at specific lysine residues regulates...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398484/ https://www.ncbi.nlm.nih.gov/pubmed/18716620 http://dx.doi.org/10.1038/nature07290 |