Loss of Activating EGFR Mutant Gene Contributes to Acquired Resistance to EGFR Tyrosine Kinase Inhibitors in Lung Cancer Cells

Non-small-cell lung cancer harboring epidermal growth factor receptor (EGFR) mutations attains a meaningful response to EGFR-tyrosine kinase inhibitors (TKIs). However, acquired resistance to EGFR-TKIs could affect long-term outcome in almost all patients. To identify the potential mechanisms of res...

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Detalles Bibliográficos
Autores principales: Tabara, Keisuke, Kanda, Rina, Sonoda, Kahori, Kubo, Takuya, Murakami, Yuichi, Kawahara, Akihiko, Azuma, Koichi, Abe, Hideyuki, Kage, Masayoshi, Yoshinaga, Aki, Tahira, Tomoko, Hayashi, Kenshi, Arao, Tokuzo, Nishio, Kazuto, Rosell, Rafael, Kuwano, Michihiko, Ono, Mayumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398867/
https://www.ncbi.nlm.nih.gov/pubmed/22815900
http://dx.doi.org/10.1371/journal.pone.0041017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398867/
https://www.ncbi.nlm.nih.gov/pubmed/22815900
http://dx.doi.org/10.1371/journal.pone.0041017

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