Germline Deletion of Pantothenate Kinases 1 and 2 Reveals the Key Roles for CoA in Postnatal Metabolism

Pantothenate kinase (PanK) phosphorylates pantothenic acid (vitamin B(5)) and controls the overall rate of coenzyme A (CoA) biosynthesis. Pank1 gene deletion in mice results in a metabolic phenotype where fatty acid oxidation and gluconeogenesis are impaired in the fasted state, leading to mild hypo...

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Detalles Bibliográficos
Autores principales: Garcia, Matthew, Leonardi, Roberta, Zhang, Yong-Mei, Rehg, Jerold E., Jackowski, Suzanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398950/
https://www.ncbi.nlm.nih.gov/pubmed/22815849
http://dx.doi.org/10.1371/journal.pone.0040871

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398950/
https://www.ncbi.nlm.nih.gov/pubmed/22815849
http://dx.doi.org/10.1371/journal.pone.0040871

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