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Deciphering the Role of Insulin-Like Growth Factor-I Receptor in Trastuzumab Resistance
Resistance to the HER2-targeted antibody trastuzumab is a major clinical concern in the treatment of HER2-overexpressing metastatic breast cancer. Increased expression or signaling of the insulin-like growth factor-I receptor (IGF-IR) has been reported in a subset of cell lines and clinical samples...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Hindawi Publishing Corporation
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399380/ https://www.ncbi.nlm.nih.gov/pubmed/22830017 http://dx.doi.org/10.1155/2012/648965 |