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The role of Bax and caspase-3 in doppel-induced apoptosis of cerebellar granule cells

Doppel (Dpl) protein is a paralog of the prion protein (PrP) that shares 25% sequence similarity with the C-terminus of PrP, a common N-glycosylation site and a C-terminal signal peptide for attachment of a glycosylphophatidyl inositol anchor. Whereas PrP(C) is highly expressed in the central nervou...

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Detalles Bibliográficos
Autores principales: Didonna, Alessandro, Sussman, Joshua, Benetti, Federico, Legname, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399532/
https://www.ncbi.nlm.nih.gov/pubmed/22561161
http://dx.doi.org/10.4161/pri.20026