Monomerization of Viral Entry Inhibitor Griffithsin Elucidates the Relationship between Multivalent Binding to Carbohydrates and anti-HIV Activity

Mutations were introduced to the domain-swapped homodimer of the antiviral lectin griffithsin (GRFT). Whereas several single and double mutants remained dimeric, insertion of either two or four amino acids at the dimerization interface resulted in a monomeric form of the protein (mGRFT). Monomeric c...

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Detalles Bibliográficos
Autores principales: Moulaei, Tinoush, Shenoy, Shilpa R., Giomarelli, Barbara, Thomas, Cheryl, McMahon, James B., Dauter, Zbigniew, O'Keefe, Barry R., Wlodawer, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399781/
https://www.ncbi.nlm.nih.gov/pubmed/20826337
http://dx.doi.org/10.1016/j.str.2010.05.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399781/
https://www.ncbi.nlm.nih.gov/pubmed/20826337
http://dx.doi.org/10.1016/j.str.2010.05.016

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