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Pak1 Regulates the Orientation of Apical Polarization and Lumen Formation by Distinct Pathways

The development of the basic architecture of branching tubules enclosing a central lumen that characterizes most epithelial organs crucially depends on the apico-basolateral polarization of epithelial cells. Signals from the extracellular matrix control the orientation of the apical surface, so that...

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Detalles Bibliográficos
Autores principales: deLeon, Orlando, Puglise, Jason M., Liu, Fengming, Smits, Jos, ter Beest, Martin B., Zegers, Mirjam M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399788/
https://www.ncbi.nlm.nih.gov/pubmed/22815903
http://dx.doi.org/10.1371/journal.pone.0041039