Promoters Are Differentially Sensitive to N-Terminal Mutant Huntingtin-Mediated Transcriptional Repression

Huntington’s disease (HD) is a neurodegenerative disorder caused by the inheritance of one mutant copy of the huntingtin gene. Mutant huntingtin protein (mHtt) contains an expanded polyglutamine repeat region near the N-terminus. Cleavage of mHtt releases an N-terminal fragment (N-mHtt) which accumu...

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Detalles Bibliográficos
Autores principales: Hogel, Matthew, Laprairie, Robert B., Denovan-Wright, Eileen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399790/
https://www.ncbi.nlm.nih.gov/pubmed/22815947
http://dx.doi.org/10.1371/journal.pone.0041152

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399790/
https://www.ncbi.nlm.nih.gov/pubmed/22815947
http://dx.doi.org/10.1371/journal.pone.0041152

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