A Novel Way to Grow Hemozoin-Like Crystals In Vitro and Its Use to Screen for Hemozoin Inhibiting Antimalarial Compounds

BACKGROUND: Hemozoin crystals are normally formed in vivo by Plasmodium parasites to detoxify free heme released after hemoglobin digestion during its intraerythrocytic stage. Inhibition of hemozoin formation by various drugs results in free heme concentration toxic for the parasites. As a consequen...

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Detalles Bibliográficos
Autores principales: Thomas, Vincent, Góis, Ana, Ritts, Bruce, Burke, Peter, Hänscheid, Thomas, McDonnell, Gerald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399802/
https://www.ncbi.nlm.nih.gov/pubmed/22815894
http://dx.doi.org/10.1371/journal.pone.0041006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399802/
https://www.ncbi.nlm.nih.gov/pubmed/22815894
http://dx.doi.org/10.1371/journal.pone.0041006

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