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A Novel Way to Grow Hemozoin-Like Crystals In Vitro and Its Use to Screen for Hemozoin Inhibiting Antimalarial Compounds
BACKGROUND: Hemozoin crystals are normally formed in vivo by Plasmodium parasites to detoxify free heme released after hemoglobin digestion during its intraerythrocytic stage. Inhibition of hemozoin formation by various drugs results in free heme concentration toxic for the parasites. As a consequen...
Autores principales: | Thomas, Vincent, Góis, Ana, Ritts, Bruce, Burke, Peter, Hänscheid, Thomas, McDonnell, Gerald |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399802/ https://www.ncbi.nlm.nih.gov/pubmed/22815894 http://dx.doi.org/10.1371/journal.pone.0041006 |
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