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Exploring IRES Region Accessibility by Interference of Foot-and-Mouth Disease Virus Infectivity

Translation initiation of picornavirus RNA is driven by an internal ribosome entry site (IRES) element located upstream of the initiator codon. RNA structure organization as well as RNA-protein interaction plays a fundamental role in internal initiation. IRES activity has been mainly analyzed in the...

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Detalles Bibliográficos
Autores principales: Fajardo, Teodoro, Rosas, Maria Flora, Sobrino, Francisco, Martinez-Salas, Encarnacion
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399821/
https://www.ncbi.nlm.nih.gov/pubmed/22815996
http://dx.doi.org/10.1371/journal.pone.0041382