Mechanical Stretch and PI3K Signaling Link Cell Migration and Proliferation to Coordinate Epithelial Tubule Morphogenesis in the Zebrafish Pronephros

Organ development leads to the emergence of organ function, which in turn can impact developmental processes. Here we show that fluid flow-induced collective epithelial migration during kidney nephron morphogenesis induces cell stretch that in turn signals epithelial proliferation. Increased cell pr...

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Detalles Bibliográficos
Autores principales: Vasilyev, Aleksandr, Liu, Yan, Hellman, Nathan, Pathak, Narendra, Drummond, Iain A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399848/
https://www.ncbi.nlm.nih.gov/pubmed/22815719
http://dx.doi.org/10.1371/journal.pone.0039992

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399848/
https://www.ncbi.nlm.nih.gov/pubmed/22815719
http://dx.doi.org/10.1371/journal.pone.0039992

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