Novel RNAi-Mediated Approach to G Protein-Coupled Receptor Deorphanization: Proof of Principle and Characterization of a Planarian 5-HT Receptor

G protein-coupled receptors (GPCRs) represent the largest known superfamily of membrane proteins extending throughout the Metazoa. There exists ample motivation to elucidate the functional properties of GPCRs given their role in signal transduction and their prominence as drug targets. In many targe...

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Detalles Bibliográficos
Autores principales: Zamanian, Mostafa, Agbedanu, Prince N., Wheeler, Nicolas J., McVeigh, Paul, Kimber, Michael J., Day, Tim A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399857/
https://www.ncbi.nlm.nih.gov/pubmed/22815820
http://dx.doi.org/10.1371/journal.pone.0040787

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399857/
https://www.ncbi.nlm.nih.gov/pubmed/22815820
http://dx.doi.org/10.1371/journal.pone.0040787

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