Pharmacological Inhibition of Microsomal Prostaglandin E Synthase-1 Suppresses Epidermal Growth Factor Receptor-Mediated Tumor Growth and Angiogenesis

BACKGROUND: Blockade of Prostaglandin (PG) E(2) production via deletion of microsomal Prostaglandin E synthase-1 (mPGES-1) gene reduces tumor cell proliferation in vitro and in vivo on xenograft tumors. So far the therapeutic potential of the pharmacological inhibition of mPGES-1 has not been elucid...

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Detalles Bibliográficos
Autores principales: Finetti, Federica, Terzuoli, Erika, Bocci, Elena, Coletta, Isabella, Polenzani, Lorenzo, Mangano, Giorgina, Alisi, Maria Alessandra, Cazzolla, Nicola, Giachetti, Antonio, Ziche, Marina, Donnini, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399882/
https://www.ncbi.nlm.nih.gov/pubmed/22815767
http://dx.doi.org/10.1371/journal.pone.0040576

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399882/
https://www.ncbi.nlm.nih.gov/pubmed/22815767
http://dx.doi.org/10.1371/journal.pone.0040576

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