Ectopically Expressed Perforin-1 Is Proapoptotic in Tumor Cell Lines by Increasing Caspase-3 Activity and the Nuclear Translocation of Cytochrome c

Perforin-1 (PRF), a cytotoxic lymphocyte pore-forming protein, plays an important role in the action of cytotoxic T cells and natural killer cells in that it causes the lysis of abnormal body cells and the elimination of virus-infected cells and tumors. Upon degranulation, PRF inserts itself into th...

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Detalles Bibliográficos
Autores principales: Wang, Li-Feng, Wang, Fang, Li, Jun-Tang, Wen, Wei-Hong, Zhao, Jing, Jia, Lin-Tao, Meng, Yan-Ling, Cao, Yun-Xin, Yao, Li-Bo, Chen, Si-Yi, Xu, Yan-Ming, Yang, An-Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400674/
https://www.ncbi.nlm.nih.gov/pubmed/22829880
http://dx.doi.org/10.1371/journal.pone.0040639

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400674/
https://www.ncbi.nlm.nih.gov/pubmed/22829880
http://dx.doi.org/10.1371/journal.pone.0040639

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