A Small-Molecule Probe of the Histone Methyltransferase G9a Induces Cellular Senescence in Pancreatic Adenocarcinoma

[Image: see text] Post-translational modifications of histones alter chromatin structure and play key roles in gene expression and specification of cell states. Small molecules that target chromatin-modifying enzymes selectively are useful as probes and have promise as therapeutics, although very fe...

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Detalles Bibliográficos
Autores principales: Yuan, Yuan, Wang, Qiu, Paulk, Joshiawa, Kubicek, Stefan, Kemp, Melissa M., Adams, Drew J., Shamji, Alykhan F., Wagner, Bridget K., Schreiber, Stuart L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401036/
https://www.ncbi.nlm.nih.gov/pubmed/22536950
http://dx.doi.org/10.1021/cb300139y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401036/
https://www.ncbi.nlm.nih.gov/pubmed/22536950
http://dx.doi.org/10.1021/cb300139y

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