Mitochondrial Topoisomerase I is Critical for Mitochondrial Integrity and Cellular Energy Metabolism

BACKGROUND: Mitochondria contain their own DNA genome (mtDNA), as well as specific DNA replication and protein synthesis machineries. Relaxation of the circular, double-stranded mtDNA relies on the presence of topoisomerase activity. Three different topoisomerases have been identified in mitochondri...

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Detalles Bibliográficos
Autores principales: Douarre, Céline, Sourbier, Carole, Dalla Rosa, Ilaria, Brata Das, Benu, Redon, Christophe E., Zhang, Hongliang, Neckers, Len, Pommier, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401127/
https://www.ncbi.nlm.nih.gov/pubmed/22911747
http://dx.doi.org/10.1371/journal.pone.0041094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401127/
https://www.ncbi.nlm.nih.gov/pubmed/22911747
http://dx.doi.org/10.1371/journal.pone.0041094

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