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Mitochondrial Topoisomerase I is Critical for Mitochondrial Integrity and Cellular Energy Metabolism
BACKGROUND: Mitochondria contain their own DNA genome (mtDNA), as well as specific DNA replication and protein synthesis machineries. Relaxation of the circular, double-stranded mtDNA relies on the presence of topoisomerase activity. Three different topoisomerases have been identified in mitochondri...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401127/ https://www.ncbi.nlm.nih.gov/pubmed/22911747 http://dx.doi.org/10.1371/journal.pone.0041094 |