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M6P/IGF2R modulates the invasiveness of liver cells via its capacity to bind mannose 6-phosphate residues

BACKGROUND & AIMS: The mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R), a multifunctional protein, plays a central role in intracellular targeting of lysosomal enzymes and control of insulin-like growth factor II (IGF-II) bioactivity. Importantly, the gene encoding this re...

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Detalles Bibliográficos
Autores principales: Puxbaum, Verena, Nimmerfall, Elisabeth, Bäuerl, Christine, Taub, Nicole, Blaas, Pia-Maria, Wieser, Johannes, Mikula, Mario, Mikulits, Wolfgang, Ng, Ken M., Yeoh, George C.T., Mach, Lukas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401376/
https://www.ncbi.nlm.nih.gov/pubmed/22521359
http://dx.doi.org/10.1016/j.jhep.2012.03.026