siRNAs targeted to certain polyadenylation sites promote specific, RISC-independent degradation of messenger RNAs

While most siRNAs induce sequence-specific target mRNA cleavage and degradation in a process mediated by Ago2/RNA-induced silencing complex (RISC), certain siRNAs have also been demonstrated to direct target RNA reduction through deadenylation and subsequent degradation of target transcripts in a pr...

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Detalles Bibliográficos
Autores principales: Vickers, Timothy A., Crooke, Stanley T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401429/
https://www.ncbi.nlm.nih.gov/pubmed/22422842
http://dx.doi.org/10.1093/nar/gks239

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401429/
https://www.ncbi.nlm.nih.gov/pubmed/22422842
http://dx.doi.org/10.1093/nar/gks239

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