Collaborative coupling between polymerase and helicase for leading-strand synthesis

Rapid and processive leading-strand DNA synthesis in the bacteriophage T4 system requires functional coupling between the helicase and the holoenzyme, consisting of the polymerase and trimeric clamp loaded by the clamp loader. We investigated the mechanism of this coupling on a DNA hairpin substrate...

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Detalles Bibliográficos
Autores principales: Manosas, Maria, Spiering, Michelle M., Ding, Fangyuan, Croquette, Vincent, Benkovic, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401439/
https://www.ncbi.nlm.nih.gov/pubmed/22434886
http://dx.doi.org/10.1093/nar/gks254

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401439/
https://www.ncbi.nlm.nih.gov/pubmed/22434886
http://dx.doi.org/10.1093/nar/gks254

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