Genome-wide profiles of H2AX and γ-H2AX differentiate endogenous and exogenous DNA damage hotspots in human cells

Phosphorylation of the histone variant H2AX forms γ-H2AX that marks DNA double-strand break (DSB). Here, we generated the sequencing-based maps of H2AX and γ-H2AX positioning in resting and proliferating cells before and after ionizing irradiation. Genome-wide locations of possible endogenous and ex...

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Detalles Bibliográficos
Autores principales: Seo, Jungmin, Kim, Sang Cheol, Lee, Heun-Sik, Kim, Jung Kyu, Shon, Hye Jin, Salleh, Nur Lina Mohd, Desai, Kartiki Vasant, Lee, Jae Ho, Kang, Eun-Suk, Kim, Jin Sung, Choi, Jung Kyoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401470/
https://www.ncbi.nlm.nih.gov/pubmed/22467212
http://dx.doi.org/10.1093/nar/gks287

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401470/
https://www.ncbi.nlm.nih.gov/pubmed/22467212
http://dx.doi.org/10.1093/nar/gks287

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