Elimination of the Actin-Binding Domain in Kelch-Like 1 Protein Induces T-Type Calcium Channel Modulation Only in the Presence of Action Potential Waveforms

The Kelch-like 1 protein (KLHL1) is a neuronal actin-binding protein that modulates calcium channel function. It increases the current density of Ca(v)3.2 (α (1H)) calcium channels via direct interaction with α (1H) and actin-F, resulting in biophysical changes in Ca(v)3.2 currents and an increase i...

Descripción completa

Detalles Bibliográficos
Autores principales: Aromolaran, Kelly A., Benzow, Kelly A., Cribbs, Leanne L., Koob, Michael D., Piedras-Rentería, Erika S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401526/
https://www.ncbi.nlm.nih.gov/pubmed/22848812
http://dx.doi.org/10.1155/2012/505346

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401526/
https://www.ncbi.nlm.nih.gov/pubmed/22848812
http://dx.doi.org/10.1155/2012/505346

Ejemplares similares