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Elimination of the Actin-Binding Domain in Kelch-Like 1 Protein Induces T-Type Calcium Channel Modulation Only in the Presence of Action Potential Waveforms

The Kelch-like 1 protein (KLHL1) is a neuronal actin-binding protein that modulates calcium channel function. It increases the current density of Ca(v)3.2 (α (1H)) calcium channels via direct interaction with α (1H) and actin-F, resulting in biophysical changes in Ca(v)3.2 currents and an increase i...

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Detalles Bibliográficos
Autores principales:	Aromolaran, Kelly A., Benzow, Kelly A., Cribbs, Leanne L., Koob, Michael D., Piedras-Rentería, Erika S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401526/ https://www.ncbi.nlm.nih.gov/pubmed/22848812 http://dx.doi.org/10.1155/2012/505346

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