Modification of γ-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease

Inherited familial Alzheimer's disease (AD) is characterized by small increases in the ratio of Aβ42 versus Aβ40 peptide which is thought to drive the amyloid plaque formation in the brain of these patients. Little is known however whether ageing, the major risk factor for sporadic AD, affects...

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Detalles Bibliográficos
Autores principales: Guix, Francesc X, Wahle, Tina, Vennekens, Kristel, Snellinx, An, Chávez-Gutiérrez, Lucía, Ill-Raga, Gerard, Ramos-Fernandez, Eva, Guardia-Laguarta, Cristina, Lleó, Alberto, Arimon, Muriel, Berezovska, Oksana, Muñoz, Francisco J, Dotti, Carlos G, De Strooper, Bart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2012
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402223/
https://www.ncbi.nlm.nih.gov/pubmed/22488900
http://dx.doi.org/10.1002/emmm.201200243

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402223/
https://www.ncbi.nlm.nih.gov/pubmed/22488900
http://dx.doi.org/10.1002/emmm.201200243

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