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Modification of γ-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease
Inherited familial Alzheimer's disease (AD) is characterized by small increases in the ratio of Aβ42 versus Aβ40 peptide which is thought to drive the amyloid plaque formation in the brain of these patients. Little is known however whether ageing, the major risk factor for sporadic AD, affects...
Autores principales: | Guix, Francesc X, Wahle, Tina, Vennekens, Kristel, Snellinx, An, Chávez-Gutiérrez, Lucía, Ill-Raga, Gerard, Ramos-Fernandez, Eva, Guardia-Laguarta, Cristina, Lleó, Alberto, Arimon, Muriel, Berezovska, Oksana, Muñoz, Francisco J, Dotti, Carlos G, De Strooper, Bart |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
WILEY-VCH Verlag
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402223/ https://www.ncbi.nlm.nih.gov/pubmed/22488900 http://dx.doi.org/10.1002/emmm.201200243 |
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