Cargando…

Nesfatin-1 Action in the Brain Increases Insulin Sensitivity Through Akt/AMPK/TORC2 Pathway in Diet-Induced Insulin Resistance

Nesfatin-1, derived from nucleobindin 2, was recently identified as an anorexigenic signal peptide. However, its neural role in glucose homeostasis and insulin sensitivity is unknown. To evaluate the metabolic impact and underlying mechanisms of central nesfatin-1 signaling, we infused nesfatin-1 in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Mengliu, Zhang, Zhihong, Wang, Chong, Li, Ke, Li, Shengbing, Boden, Guenther, Li, Ling, Yang, Gangyi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2012
Materias:	Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402309/ https://www.ncbi.nlm.nih.gov/pubmed/22688332 http://dx.doi.org/10.2337/db11-1755

Ejemplares similares

Liraglutide Increases FGF-21 Activity and Insulin Sensitivity in High Fat Diet and Adiponectin Knockdown Induced Insulin Resistance
por: Yang, Mengliu, et al.
Publicado: (2012)

NAMPT knockdown attenuates atherosclerosis and promotes reverse cholesterol transport in ApoE KO mice with high-fat-induced insulin resistance
por: Li, Shengbing, et al.
Publicado: (2016)

Diurnal Pattern to Insulin Secretion and Insulin Action in Healthy Individuals
por: Saad, Ahmed, et al.
Publicado: (2012)

Insulin Resistance Is Associated With Diminished Endoplasmic Reticulum Stress Responses in Adipose Tissue of Healthy and Diabetic Subjects
por: Boden, Guenther, et al.
Publicado: (2014)

Zinc-α(2)-Glycoprotein Is Associated With Insulin Resistance in Humans and Is Regulated by Hyperglycemia, Hyperinsulinemia, or Liraglutide Administration: Cross-sectional and interventional studies in normal subjects, insulin-resistant subjects, and subjects with newly diagnosed diabetes
por: Yang, Mengliu, et al.
Publicado: (2013)

Pulsatile Portal Vein Insulin Delivery Enhances Hepatic Insulin Action and Signaling
por: Matveyenko, Aleksey V., et al.
Publicado: (2012)

Insulin Regulates the Unfolded Protein Response in Human Adipose Tissue
por: Boden, Guenther, et al.
Publicado: (2014)

Insulin Receptor Signaling in POMC, but Not AgRP, Neurons Controls Adipose Tissue Insulin Action
por: Shin, Andrew C., et al.
Publicado: (2017)

Heterozygous SOD2 Deletion Impairs Glucose-Stimulated Insulin Secretion, but Not Insulin Action, in High-Fat–Fed Mice
por: Kang, Li, et al.
Publicado: (2014)

Failure of Homeostatic Model Assessment of Insulin Resistance to Detect Marked Diet-Induced Insulin Resistance in Dogs
por: Ader, Marilyn, et al.
Publicado: (2014)

Leucine Deprivation Increases Hepatic Insulin Sensitivity via GCN2/mTOR/S6K1 and AMPK Pathways
por: Xiao, Fei, et al.
Publicado: (2011)

AMPK and Insulin Action - Responses to Ageing and High Fat Diet
por: Frøsig, Christian, et al.
Publicado: (2013)

SIRT3 Is Crucial for Maintaining Skeletal Muscle Insulin Action and Protects Against Severe Insulin Resistance in High-Fat–Fed Mice
por: Lantier, Louise, et al.
Publicado: (2015)

Efficacy and Safety of Aldose Reductase Inhibitor for the Treatment of Diabetic Cardiovascular Autonomic Neuropathy: Systematic Review and Meta-Analysis
por: Hu, Xin, et al.
Publicado: (2014)

Downregulation of AMPK Accompanies Leucine- and Glucose-Induced Increases in Protein Synthesis and Insulin Resistance in Rat Skeletal Muscle
por: Saha, Asish K., et al.
Publicado: (2010)

Genistein stimulates insulin sensitivity through gut microbiota reshaping and skeletal muscle AMPK activation in obese subjects
por: Guevara-Cruz, Martha, et al.
Publicado: (2020)

Insulin Augmentation of Glucose-Stimulated Insulin Secretion Is Impaired in Insulin-Resistant Humans
por: Halperin, Florencia, et al.
Publicado: (2012)

Efficacy of nanocurcumin supplementation on insulin resistance, lipids, inflammatory factors and nesfatin among obese patients with non-alcoholic fatty liver disease (NAFLD): a trial protocol
por: Jazayeri-Tehrani, Seyed Ali, et al.
Publicado: (2017)

Effects of Short-Term Continuous Subcutaneous Insulin Infusion on Fasting Plasma Fibroblast Growth Factor-21 Levels in Patients with Newly Diagnosed Type 2 Diabetes Mellitus
por: Yang, Mengliu, et al.
Publicado: (2011)

Mediobasal Hypothalamic SIRT1 Is Essential for Resveratrol’s Effects on Insulin Action in Rats
por: Knight, Colette M., et al.
Publicado: (2011)

Diabetes in Mice With Selective Impairment of Insulin Action in Glut4-Expressing Tissues
por: Lin, Hua V., et al.
Publicado: (2011)

Integrin-Linked Kinase in Muscle Is Necessary for the Development of Insulin Resistance in Diet-Induced Obese Mice
por: Kang, Li, et al.
Publicado: (2016)

Forced Hepatic Overexpression of CEACAM1 Curtails Diet-Induced Insulin Resistance
por: Al-Share, Qusai Y., et al.
Publicado: (2015)

Integrin-Linked Kinase Is Necessary for the Development of Diet-Induced Hepatic Insulin Resistance
por: Williams, Ashley S., et al.
Publicado: (2017)

Variability of Directly Measured First-Pass Hepatic Insulin Extraction and Its Association With Insulin Sensitivity and Plasma Insulin
por: Asare-Bediako, Isaac, et al.
Publicado: (2018)

AMP-Activated Protein Kinase α1 Protects Against Diet-Induced Insulin Resistance and Obesity
por: Zhang, Weiyu, et al.
Publicado: (2012)

Nobiletin Attenuates VLDL Overproduction, Dyslipidemia, and Atherosclerosis in Mice With Diet-Induced Insulin Resistance
por: Mulvihill, Erin E., et al.
Publicado: (2011)

Intraperitoneal insulin administration in pigs: effect on circulating insulin and glucose levels
por: Dirnena-Fusini, Ilze, et al.
Publicado: (2021)

CGI-58/ABHD5-Derived Signaling Lipids Regulate Systemic Inflammation and Insulin Action
por: Lord, Caleb C., et al.
Publicado: (2012)

Nonthyrotoxic Prevention of Diet-Induced Insulin Resistance by 3,5-Diiodo-L-Thyronine in Rats
por: de Lange, Pieter, et al.
Publicado: (2011)

Inhibition of Carnitine Palmitoyltransferase-1 Activity Alleviates Insulin Resistance in Diet-Induced Obese Mice
por: Keung, Wendy, et al.
Publicado: (2013)

Recombinant Human Leptin Treatment Does Not Improve Insulin Action in Obese Subjects With Type 2 Diabetes
por: Mittendorfer, Bettina, et al.
Publicado: (2011)

Diet-Induced Muscle Insulin Resistance Is Associated With Extracellular Matrix Remodeling and Interaction With Integrin α(2)β(1) in Mice
por: Kang, Li, et al.
Publicado: (2011)

Lipid-Induced Insulin Resistance Is Not Mediated by Impaired Transcapillary Transport of Insulin and Glucose in Humans
por: Szendroedi, Julia, et al.
Publicado: (2012)

Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance
por: Vazirani, Reema P., et al.
Publicado: (2016)

Insulin enhances renal glucose excretion: relation to insulin sensitivity and sodium-glucose cotransport
por: Ferrannini, Ele, et al.
Publicado: (2020)

Adiponectin/(FBG × FIns) as a predictor of insulin sensitivity and metabolic syndrome in patients with polycystic ovary syndrome
por: Xu, Xiaohui, et al.
Publicado: (2016)

Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance
por: Zhou, Meiyi, et al.
Publicado: (2019)

A Novel Pleckstrin Homology Domain-containing Protein Enhances Insulin-stimulated Akt Phosphorylation and GLUT4 Translocation in Adipocytes
por: Zhou, Qiong L., et al.
Publicado: (2010)

Overexpression of Sphingosine Kinase 1 Prevents Ceramide Accumulation and Ameliorates Muscle Insulin Resistance in High-Fat Diet–Fed Mice
por: Bruce, Clinton R., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_desgnv2rm52384e9tij6poufvs