Hepatocyte-Specific Ptpn6 Deletion Protects From Obesity-Linked Hepatic Insulin Resistance

The protein-tyrosine phosphatase Shp1 negatively regulates insulin action on glucose homeostasis in liver and muscle, but its potential role in obesity-linked insulin resistance has not been examined. To investigate the role of Shp1 in hepatic insulin resistance, we generated hepatocyte-specific Shp...

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Detalles Bibliográficos
Autores principales: Xu, Elaine, Charbonneau, Alexandre, Rolland, Yannève, Bellmann, Kerstin, Pao, Lily, Siminovitch, Katherine A., Neel, Benjamin G., Beauchemin, Nicole, Marette, André
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2012
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402325/
https://www.ncbi.nlm.nih.gov/pubmed/22698917
http://dx.doi.org/10.2337/db11-1502

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402325/
https://www.ncbi.nlm.nih.gov/pubmed/22698917
http://dx.doi.org/10.2337/db11-1502

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