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Hepatocyte-Specific Ptpn6 Deletion Protects From Obesity-Linked Hepatic Insulin Resistance
The protein-tyrosine phosphatase Shp1 negatively regulates insulin action on glucose homeostasis in liver and muscle, but its potential role in obesity-linked insulin resistance has not been examined. To investigate the role of Shp1 in hepatic insulin resistance, we generated hepatocyte-specific Shp...
Autores principales: | Xu, Elaine, Charbonneau, Alexandre, Rolland, Yannève, Bellmann, Kerstin, Pao, Lily, Siminovitch, Katherine A., Neel, Benjamin G., Beauchemin, Nicole, Marette, André |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402325/ https://www.ncbi.nlm.nih.gov/pubmed/22698917 http://dx.doi.org/10.2337/db11-1502 |
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