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Restoration of Corticosteroid Sensitivity by p38 Mitogen Activated Protein Kinase Inhibition in Peripheral Blood Mononuclear Cells from Severe Asthma

BACKGROUND: Severe asthma accounts for a small number of asthmatics but represents a disproportionate cost to health care systems. The underlying mechanism in severe asthma remains unknown but several mechanisms are likely to be involved because of a very heterogeneous profile. We investigated the e...

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Detalles Bibliográficos
Autores principales: Mercado, Nicolas, Hakim, Amir, Kobayashi, Yoshiki, Meah, Sally, Usmani, Omar S., Chung, Kian Fan, Barnes, Peter J., Ito, Kazuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402424/
https://www.ncbi.nlm.nih.gov/pubmed/22911818
http://dx.doi.org/10.1371/journal.pone.0041582