Cargando…

Cyproheptadine Enhances the I (K) of Mouse Cortical Neurons through Sigma-1 Receptor-Mediated Intracellular Signal Pathway

Cyproheptadine (CPH) is a histamine- and serotonin-receptor antagonist, and its effects are observed recently in the modulation of multiple intracellular signals. In this study, we used cortical neurons and HEK-293 cells transfected with Kv2.1 α-subunit to address whether CPH modify neural voltage-g...

Descripción completa

Detalles Bibliográficos
Autores principales:	He, Yan-Lin, Zhang, Chun-Lei, Gao, Xiao-Fei, Yao, Jin-Jing, Hu, Chang-Long, Mei, Yan-Ai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402501/ https://www.ncbi.nlm.nih.gov/pubmed/22844454 http://dx.doi.org/10.1371/journal.pone.0041303

Ejemplares similares

Cyproheptadine-Induced Acute Liver Failure
por: Chertoff, Jason, et al.
Publicado: (2014)

Hyperthermia and Serotonin: The Quest for a “Better Cyproheptadine”
por: Petroianu, Georg A.
Publicado: (2022)

Cytotoxicity of cyproheptadine and methysergide to chemically induced carcinomas of rat colon.
por: Barkla, D. H., et al.
Publicado: (1977)

Extraction and Determination of Cyproheptadine in Human Urine by DLLME-HPLC Method
por: Maham, Mehdi, et al.
Publicado: (2013)

Preventive effect of cyproheptadine hydrochloride in refractory patients with frequent migraine
por: Okuma, Hirohisa, et al.
Publicado: (2013)

When Too Much Is Enough: Pediatric Cyproheptadine Overdose with Confirmatory Level
por: McGovern, Terrance, et al.
Publicado: (2017)

Therapeutic cyproheptadine regimen in serotonin syndrome: Complications after cardiovascular surgery
por: Nagy, Ahmed, et al.
Publicado: (2023)

Efficacy of Cyproheptadine Monotherapy in Hepatocellular Carcinoma With Bone Metastasis: A Case Report
por: Feng, Yu-Min, et al.
Publicado: (2021)

Ligand-dependent localization and intracellular stability of sigma-1 receptors in CHO-K1 cells
por: Mavlyutov, Timur A, et al.
Publicado: (2007)

Sigma-1 Receptor Agonists Directly Inhibit Na(V)1.2/1.4 Channels
por: Gao, Xiao-Fei, et al.
Publicado: (2012)

The Antidepressant 5-HT(2A) Receptor Antagonists Pizotifen and Cyproheptadine Inhibit Serotonin-Enhanced Platelet Function
por: Lin, Olivia A., et al.
Publicado: (2014)

Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep–wake states
por: Natsubori, Akiyo, et al.
Publicado: (2020)

Beneficial Effect of Cyproheptadine on Body Mass Index in Undernourished Children: A Randomized Controlled Trial
por: Najib, Khadijehsadat, et al.
Publicado: (2014)

Cyproheptadine significantly improves the overall and progression-free survival of sorafenib-treated advanced HCC patients
por: Feng, Yu-Min, et al.
Publicado: (2015)

Loxapine and Cyproheptadine Combined Limit Clozapine Rebound Psychosis and May Also Predict Clozapine Response
por: Aboueid, Lila, et al.
Publicado: (2016)

Safety of Cyproheptadine, an Orexigenic Drug. Analysis of the French National Pharmacovigilance Data-Base and Systematic Review
por: Bertrand, Valérie, et al.
Publicado: (2021)

Off-Label Cyproheptadine in Children and Adolescents: Psychiatric Comorbidities, Interacting Variables, Safety, and Risks of Hepatotoxicity
por: Gupta, Mayank, et al.
Publicado: (2023)

Effects of cyproheptadine on body weight gain in children with nonorganic failure to thrive in Taiwan: A hospital-based retrospective study
por: Lin, Yi-Chun, et al.
Publicado: (2021)

The Role of Sigma-1 Receptor, an Intracellular Chaperone in Neurodegenerative Diseases
por: Penke, Botond, et al.
Publicado: (2018)

The misuse of Cyproheptadine: a non-communicable disease risk behaviour in Kinshasa population, Democratic Republic of Congo
por: Lulebo, Aimée M., et al.
Publicado: (2016)

Serotonergic neurons control cortical neuronal intracellular energy dynamics by modulating astrocyte-neuron lactate shuttle
por: Natsubori, Akiyo, et al.
Publicado: (2023)

Cyproheptadine, an epigenetic modifier, exhibits anti-tumor activity by reversing the epigenetic silencing of IRF6 in urothelial carcinoma
por: Jou, Yeong-Chin, et al.
Publicado: (2021)

Neurotransmitter Receptor Bases of the Long-Rage Interactions of Cat Striate Cortical Neurons Revealed by In-Vivo Intracellular Injection
por: Song, Xue-Mei, et al.
Publicado: (2011)

Neuritin Activates Insulin Receptor Pathway to Up-regulate Kv4.2-mediated Transient Outward K(+) Current in Rat Cerebellar Granule Neurons
por: Yao, Jin-Jing, et al.
Publicado: (2012)

Electro-spinning fabrication of nitrogen, phosphorus co-doped porous carbon nanofiber as an electro-chemiluminescent sensor for the determination of cyproheptadine
por: Cheng, Hao, et al.
Publicado: (2020)

Intracellular dynamics of the Sigma-1 receptor observed with super-resolution imaging microscopy
por: Kopanchuk, Sergei, et al.
Publicado: (2022)

Sensitive Immunochromatographic Assay Using Highly Luminescent Quantum Dot Nanobeads as Tracer for the Detection of Cyproheptadine Hydrochloride in Animal-Derived Food
por: Li, Pan, et al.
Publicado: (2020)

Effect of Cyproheptadine on Ventilatory Support-free Days in Critically Ill Patients with COVID-19: An Open-label, Randomized Clinical Trial
por: Boniatti, Márcio Manozzo, et al.
Publicado: (2023)

Proposal: Direct measurement of helicity amplitudes $\pi^{+} p -> K^{+} \sigma^{+} and K^{-} p -> \pi^{-} \sigma^{+}$
por: Sadoulet, B, et al.
Publicado: (1971)

Intracellular chloride concentration of the mouse vomeronasal neuron
por: Kim, SangSeong, et al.
Publicado: (2015)

Neuronal Sirt3 Protects against Excitotoxic Injury in Mouse Cortical Neuron Culture
por: Kim, Sun Hee, et al.
Publicado: (2011)

APP-BACE1 Interaction and Intracellular Localization Regulate Aβ Production in iPSC-Derived Cortical Neurons
por: Roselli, Sandra, et al.
Publicado: (2023)

Electromagnetic production of $K\Sigma$ on the proton
por: David, J C, et al.
Publicado: (1995)

Differential development and electrophysiological activity in cultured cortical neurons from the mouse and cynomolgus monkey
por: Zhang, Xue-Yan, et al.
Publicado: (2021)

Transactivation of TrkB by Sigma-1 receptor mediates cocaine-induced changes in dendritic spine density and morphology in hippocampal and cortical neurons
por: Ka, Minhan, et al.
Publicado: (2016)

Noscapine Modulates Neuronal Response to Oxygen-glucose Deprivation/Reperfusion Injury Via Activation of Sigma-1 Receptor in Primary Cortical Cultures
por: Vahabzadeh, Gelareh, et al.
Publicado: (2020)

Sigma-1 receptor: culprit and rescuer in motor neuron diseases
por: Liévens, Jean-Charles, et al.
Publicado: (2020)

Epigenomic diversity of cortical projection neurons in the mouse brain
por: Zhang, Zhuzhu, et al.
Publicado: (2021)

Retinal Photoreceptor Protection in an AMD-Related Mouse Model by Selective Sigma-1 or Sigma-2 Receptor Modulation
por: Mavlyutov, Timur A., et al.
Publicado: (2022)

A study of the reactions $\pi^{+}p \to K^{+}\Sigma^{+}$ and $K^{-}p \to \pi^{-}\Sigma^{+}$ at 10 GeV/c
por: Berglund, A, et al.
Publicado: (1975)

Cannot write session to /tmp/vufind_sessions/sess_7m2um25arscf2mfj7t46jjv1o8