Doxycycline Regulated Induction of AKT in Murine Prostate Drives Proliferation Independently of p27 Cyclin Dependent Kinase Inhibitor Downregulation

The PI3 kinase/AKT pathway has been shown to increase degradation of the p27 cyclin dependent kinase inhibitor through phosphorylation of consensus AKT sites on p27 and SKP2, and AKT driven proliferation may be checked by feedback mechanisms that increase p27 expression and induce senescence. Howeve...

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Detalles Bibliográficos
Autores principales: Wang, Hongyun, Xu, Youyuan, Fang, Zi, Chen, Sen, Balk, Steven P., Yuan, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402521/
https://www.ncbi.nlm.nih.gov/pubmed/22844460
http://dx.doi.org/10.1371/journal.pone.0041330

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402521/
https://www.ncbi.nlm.nih.gov/pubmed/22844460
http://dx.doi.org/10.1371/journal.pone.0041330

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