Amino acid function and docking site prediction through combining disease variants, structure alignments, sequence alignments, and molecular dynamics: a study of the HMG domain

BACKGROUND: The DNA binding domain of HMG proteins is known to be important in many diseases, with the Sox sub-family of HMG proteins of particular significance. Numerous natural variants in HMG proteins are associated with disease phenotypes. Integrating these natural variants, molecular dynamic si...

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Detalles Bibliográficos
Autores principales: Prokop, Jeremy W, Leeper, Thomas C, Duan, Zhong-Hui, Milsted, Amy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402923/
https://www.ncbi.nlm.nih.gov/pubmed/22536866
http://dx.doi.org/10.1186/1471-2105-13-S2-S3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402923/
https://www.ncbi.nlm.nih.gov/pubmed/22536866
http://dx.doi.org/10.1186/1471-2105-13-S2-S3

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