Preeclampsia 2012

Preeclampsia is a common complication of pregnancy associated with high maternal morbidity and mortality and intrauterine fetal growth restriction. There is extensive evidence that the reduction of uteroplacental blood flow in this syndrome results from the toxic combination of hypoxia, imbalance of...

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Autores principales: Eiland, Elosha, Nzerue, Chike, Faulkner, Marquetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403177/
https://www.ncbi.nlm.nih.gov/pubmed/22848831
http://dx.doi.org/10.1155/2012/586578
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author Eiland, Elosha
Nzerue, Chike
Faulkner, Marquetta
author_facet Eiland, Elosha
Nzerue, Chike
Faulkner, Marquetta
author_sort Eiland, Elosha
collection PubMed
description Preeclampsia is a common complication of pregnancy associated with high maternal morbidity and mortality and intrauterine fetal growth restriction. There is extensive evidence that the reduction of uteroplacental blood flow in this syndrome results from the toxic combination of hypoxia, imbalance of angiogenic and antiangiogenic factors, inflammation, and deranged immunity. Women treated for preeclampsia also have an increased risk for cardiovascular and renal disease. At present it is unclear if the increased cardiovascular and renal disease risks are due to residual and or progressive effects of endothelial damage from the preeclampsia or from shared risk factors between preeclampsia and cardiac disease. Moreover, it appears that endothelin-1 signaling may play a central role in the hypertension associated with preeclampsia. In this paper, we discuss emerging data on the pathogenesis of preeclampsia and review therapeutic options.
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spelling pubmed-34031772012-07-30 Preeclampsia 2012 Eiland, Elosha Nzerue, Chike Faulkner, Marquetta J Pregnancy Review Article Preeclampsia is a common complication of pregnancy associated with high maternal morbidity and mortality and intrauterine fetal growth restriction. There is extensive evidence that the reduction of uteroplacental blood flow in this syndrome results from the toxic combination of hypoxia, imbalance of angiogenic and antiangiogenic factors, inflammation, and deranged immunity. Women treated for preeclampsia also have an increased risk for cardiovascular and renal disease. At present it is unclear if the increased cardiovascular and renal disease risks are due to residual and or progressive effects of endothelial damage from the preeclampsia or from shared risk factors between preeclampsia and cardiac disease. Moreover, it appears that endothelin-1 signaling may play a central role in the hypertension associated with preeclampsia. In this paper, we discuss emerging data on the pathogenesis of preeclampsia and review therapeutic options. Hindawi Publishing Corporation 2012 2012-07-11 /pmc/articles/PMC3403177/ /pubmed/22848831 http://dx.doi.org/10.1155/2012/586578 Text en Copyright © 2012 Elosha Eiland et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Eiland, Elosha
Nzerue, Chike
Faulkner, Marquetta
Preeclampsia 2012
title Preeclampsia 2012
title_full Preeclampsia 2012
title_fullStr Preeclampsia 2012
title_full_unstemmed Preeclampsia 2012
title_short Preeclampsia 2012
title_sort preeclampsia 2012
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403177/
https://www.ncbi.nlm.nih.gov/pubmed/22848831
http://dx.doi.org/10.1155/2012/586578
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