Preeclampsia 2012
Preeclampsia is a common complication of pregnancy associated with high maternal morbidity and mortality and intrauterine fetal growth restriction. There is extensive evidence that the reduction of uteroplacental blood flow in this syndrome results from the toxic combination of hypoxia, imbalance of...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403177/ https://www.ncbi.nlm.nih.gov/pubmed/22848831 http://dx.doi.org/10.1155/2012/586578 |
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author | Eiland, Elosha Nzerue, Chike Faulkner, Marquetta |
author_facet | Eiland, Elosha Nzerue, Chike Faulkner, Marquetta |
author_sort | Eiland, Elosha |
collection | PubMed |
description | Preeclampsia is a common complication of pregnancy associated with high maternal morbidity and mortality and intrauterine fetal growth restriction. There is extensive evidence that the reduction of uteroplacental blood flow in this syndrome results from the toxic combination of hypoxia, imbalance of angiogenic and antiangiogenic factors, inflammation, and deranged immunity. Women treated for preeclampsia also have an increased risk for cardiovascular and renal disease. At present it is unclear if the increased cardiovascular and renal disease risks are due to residual and or progressive effects of endothelial damage from the preeclampsia or from shared risk factors between preeclampsia and cardiac disease. Moreover, it appears that endothelin-1 signaling may play a central role in the hypertension associated with preeclampsia. In this paper, we discuss emerging data on the pathogenesis of preeclampsia and review therapeutic options. |
format | Online Article Text |
id | pubmed-3403177 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34031772012-07-30 Preeclampsia 2012 Eiland, Elosha Nzerue, Chike Faulkner, Marquetta J Pregnancy Review Article Preeclampsia is a common complication of pregnancy associated with high maternal morbidity and mortality and intrauterine fetal growth restriction. There is extensive evidence that the reduction of uteroplacental blood flow in this syndrome results from the toxic combination of hypoxia, imbalance of angiogenic and antiangiogenic factors, inflammation, and deranged immunity. Women treated for preeclampsia also have an increased risk for cardiovascular and renal disease. At present it is unclear if the increased cardiovascular and renal disease risks are due to residual and or progressive effects of endothelial damage from the preeclampsia or from shared risk factors between preeclampsia and cardiac disease. Moreover, it appears that endothelin-1 signaling may play a central role in the hypertension associated with preeclampsia. In this paper, we discuss emerging data on the pathogenesis of preeclampsia and review therapeutic options. Hindawi Publishing Corporation 2012 2012-07-11 /pmc/articles/PMC3403177/ /pubmed/22848831 http://dx.doi.org/10.1155/2012/586578 Text en Copyright © 2012 Elosha Eiland et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Eiland, Elosha Nzerue, Chike Faulkner, Marquetta Preeclampsia 2012 |
title | Preeclampsia 2012 |
title_full | Preeclampsia 2012 |
title_fullStr | Preeclampsia 2012 |
title_full_unstemmed | Preeclampsia 2012 |
title_short | Preeclampsia 2012 |
title_sort | preeclampsia 2012 |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403177/ https://www.ncbi.nlm.nih.gov/pubmed/22848831 http://dx.doi.org/10.1155/2012/586578 |
work_keys_str_mv | AT eilandelosha preeclampsia2012 AT nzeruechike preeclampsia2012 AT faulknermarquetta preeclampsia2012 |